The induction of cyclooxygenase-2 (COX-2) in cultured endothelial cells treated with serum from preeclampsia is mediated by interleukin-6.
Article
in English
| IMSEAR
| ID: sea-40792
ABSTRACT
COX-2 protein, but not COX-1 protein, was induced in HUVEC from women with a normal pregnancy (nHUVEC) treated with serum from patients with preeclampsia (pSerum), but not with serum from women with a normal pregnancy (nSerum). COX activity in pSerum treated nHUVEC was less than in nSerum treated nHUVEC. Interestingly, the induction of COX-2 protein in nHUVEC treated with pSerum was inhibited by antiIL-6 antibody. The decreased COX activity in nHUVEC treated with pSerum plus antiIL-6 antibody was also reversed in a dose dependent manner. Thus, the induction of COX-2 in pSerum treated nHUVEC was mediated by IL-6. Therefore, the development of selective inhibitors of COX-2 or of IL-6 antagonists may have a potential role in the prevention and treatment of preeclampsia.
Full text:
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Index:
IMSEAR (South-East Asia)
Main subject:
Peroxidases
/
Pre-Eclampsia
/
Female
/
Humans
/
Pregnancy
/
Cells, Cultured
/
Interleukin-6
/
Prostaglandin-Endoperoxide Synthases
/
Endothelium
/
Cyclooxygenase 2
Language:
English
Year:
1999
Type:
Article
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