Abnormal diffusivity of normal appearing brain tissue in multiple sclerosis: a diffusion-weighted MR imaging study.
Article
in English
| IMSEAR
| ID: sea-41728
ABSTRACT
OBJECTIVE:
To assess whether water diffusivity in normal appearing brain tissue including white and gray matter of multiple sclerosis (MS) patients shown by diffusion-weighted imaging (DWI) differs from normal individuals. MATERIAL ANDMETHOD:
Conventional MRI and DWI were performed in 37 multiple sclerosis patients and 31 control subjects, matched for age and sex. Quantitative diffusivity values were obtained from variable locations of normal appearing white and gray matter from both hemispheres by using a standardized region of interest template. +/- 2. 9 x 10(-5) mm2/s and 85.90 x 10(-5) +/- 2.45 x 10(-5) mm2/s) than normal control subjects (NAWM 73.46 x 10(-5) +/- 1.77 x 10(-5) mm2/s and NAGM 82.90 x 10(-5) +/- 0.91 x 10(-5) mm2/s) with p-value < 0.0001.CONCLUSION:
Water diffusivity was higher in all NAWM regions, deep gray matter regions, and some cortical gray matter region of MS patients than normal controls. DWI can quantify the presence and extent of MRI-undetectable pathology in the normal appearing brain tissue that were the disease burden.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Brain
/
Brain Diseases
/
Female
/
Humans
/
Male
/
Case-Control Studies
/
Adolescent
/
Adult
/
Diffusion Magnetic Resonance Imaging
/
Middle Aged
Type of study:
Evaluation studies
/
Observational study
Language:
English
Year:
2007
Type:
Article
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