Pharmacokinetic studies of cyclosporin in Thai kidney transplantation patients.
Article
in English
| IMSEAR
| ID: sea-41979
ABSTRACT
Pharmacokinetic studies were performed in 10 Thai patients with kidney transplantation who received microemulsion formulation (Neoral) of cyclosporin A (CsA) twice daily. No agents having pharmacokinetic effect on CsA had been used in these patients. The mean values of 12-h AUC (area under the concentration-blood curve) were 4603.63 +/- 344.61 ng x h/ml. CsA concentrations at 2 hours after dosing had the best value of correlation coefficient with the 12-h AUC. Abbreviated AUC could be calculated by stepwise multiple linear regression analysis and linear trapezoidal rule. The latter is more simple and superior to the former one.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thailand
/
Aged
/
Female
/
Humans
/
Male
/
Linear Models
/
Kidney Transplantation
/
Cyclosporine
/
Adult
/
Area Under Curve
Type of study:
Prognostic study
Country/Region as subject:
Asia
Language:
English
Year:
2000
Type:
Article
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