Medical treatment of ectopic pregnancy: a ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital.
Article
in English
| IMSEAR
| ID: sea-42340
ABSTRACT
OBJECTIVE:
To evaluate the effectiveness of single-dose intramuscular methotrexate in the treatment of ectopic pregnancy at Maharaj Nakorn Chiang Mai Hospital MATERIAL ANDMETHOD:
A retrospective review of the patient records was performed on the patients with diagnosis of ectopic pregnancy and treatment with single-dose methotrexate according to the protocol of Stovall et al between 1996 and 2005. The successful treatment was defined as no need for surgical intervention.RESULTS:
As many as 96 out of 106 (90.6%) were successfully treated with methotrexate, though four required a second dose. Pretreatment /f-human chorionic gonadotropin (beta-hCG) levels were significantly lower in women who responded to single-dose therapy than either in those who required two doses or who had a failure of medical management (p < 0. 01). The mean pretreatment level of beta-hCG was 873 mlU/ml. The median time to resolution of beta-hCG was 21 days. In addition, all cases with failed medical treatment had adnexal masses larger than 3.5 centimeters in diameterCONCLUSION:
In the present series, treatment of ectopic pregnancy with single-dose methotrexate was as high as 90% successful. Women with a high pretreatment beta-hCG level and large sonographic adnexal masses had a greater probability of requiring either surgical intervention or multiple doses of methotrexate.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pregnancy, Ectopic
/
Thailand
/
Time Factors
/
Female
/
Humans
/
Pregnancy
/
Abortifacient Agents, Nonsteroidal
/
Methotrexate
/
Retrospective Studies
/
Treatment Outcome
Type of study:
Practice guideline
/
Observational study
Country/Region as subject:
Asia
Language:
English
Year:
2006
Type:
Article
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