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Medical treatment of ectopic pregnancy: a ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital.
Article in English | IMSEAR | ID: sea-42340
ABSTRACT

OBJECTIVE:

To evaluate the effectiveness of single-dose intramuscular methotrexate in the treatment of ectopic pregnancy at Maharaj Nakorn Chiang Mai Hospital MATERIAL AND

METHOD:

A retrospective review of the patient records was performed on the patients with diagnosis of ectopic pregnancy and treatment with single-dose methotrexate according to the protocol of Stovall et al between 1996 and 2005. The successful treatment was defined as no need for surgical intervention.

RESULTS:

As many as 96 out of 106 (90.6%) were successfully treated with methotrexate, though four required a second dose. Pretreatment /f-human chorionic gonadotropin (beta-hCG) levels were significantly lower in women who responded to single-dose therapy than either in those who required two doses or who had a failure of medical management (p < 0. 01). The mean pretreatment level of beta-hCG was 873 mlU/ml. The median time to resolution of beta-hCG was 21 days. In addition, all cases with failed medical treatment had adnexal masses larger than 3.5 centimeters in diameter

CONCLUSION:

In the present series, treatment of ectopic pregnancy with single-dose methotrexate was as high as 90% successful. Women with a high pretreatment beta-hCG level and large sonographic adnexal masses had a greater probability of requiring either surgical intervention or multiple doses of methotrexate.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pregnancy, Ectopic / Thailand / Time Factors / Female / Humans / Pregnancy / Abortifacient Agents, Nonsteroidal / Methotrexate / Retrospective Studies / Treatment Outcome Type of study: Practice guideline / Observational study Country/Region as subject: Asia Language: English Year: 2006 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pregnancy, Ectopic / Thailand / Time Factors / Female / Humans / Pregnancy / Abortifacient Agents, Nonsteroidal / Methotrexate / Retrospective Studies / Treatment Outcome Type of study: Practice guideline / Observational study Country/Region as subject: Asia Language: English Year: 2006 Type: Article