Expression of E-cadherin and syndecan-1 in axillary lymph node metastases of breast cancer with and without extracapsular extension.
Article
in English
| IMSEAR
| ID: sea-42545
ABSTRACT
BACKGROUND:
Extracapsular extension of axillary lymph node (ECE) has significantly increased the risk of locoregional and distant recurrence in breast cancer patients.OBJECTIVE:
Identify markers with high biological aggressiveness since it may serve as a prognostic indicator or adjunct to standard treatment. MATERIAL ANDMETHOD:
The authors immunostained 115 axillary lymph nodes of invasive ductal carcinoma with syndecan-1 and E-cadherin.RESULTS:
The presented data shows a significantly higher number of positive lymph node (8.48 vs. 4.15; p < 0.0001) and larger primary tumor size (3.53 vs. 2.79; p = 0.0029) in ECE patients. Sixty-one cases had node positive and without evidence of ECE, 54 cases had ECE. Syndecan-1 was found to be of significantly high expression (p = 0.001). There was no significant difference in the expression of E-cadherin during progression into extracapsular area (p = 0.12).CONCLUSION:
E-cadherin displays high expression in nodal breast cancer metastases that may have re-expression and has coordinate function with syndecan-1 while invading to the surrounding fatty tissue. The protein is, therefore, likely to play a role in the invasiveness and aggressiveness.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Axilla
/
Aged, 80 and over
/
Breast Neoplasms
/
Aged
/
Female
/
Humans
/
Biomarkers, Tumor
/
Cadherins
/
Pilot Projects
Type of study:
Prognostic study
Limits:
Aged80
Language:
English
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS