Association between HLA class II alleles and autoimmune hepatitis type 1 in Thai patients.
Article
in English
| IMSEAR
| ID: sea-42667
ABSTRACT
OBJECTIVE:
To investigate the association between HLA class II alleles and autoimmune hepatitis (AIH) type I in Thai patients. MATERIAL ANDMETHOD:
The clinical data of 50 autoimmune hepatitis patients type I (AIH) at Siriraj hepatitis clinic were analysed, 37 of whom were tested for HLA class II genotyping using polymerase chain reaction and sequence-specific oligonucleotide technique (PCR-SSO).RESULTS:
AIH is an uncommon chronic hepatitis in Thailand with females predominant. The HLA DRB1*0301, and DQA1*0101 were significantly associated with AIH patients when compared to controls; (OR = 3.92 [1.18-13.30], p 0.021, OR = 2.31 [1.13-4.73], p 0.019, respectively). When 18 patients with "definite" AIH were analysed, only HLA DRB1*0301 was still significantly associated with AIH (OR = 5.22, 95%CI = 1.28-20.92, p 0.015).CONCLUSION:
HLA genotyping has shown that HLA DRB1*0301 and HLA DQA1*0101 were significantly associated with AIH.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polymorphism, Genetic
/
Autoimmune Diseases
/
Thailand
/
Aged, 80 and over
/
Aged
/
Female
/
Humans
/
Male
/
HLA-DQ Antigens
/
HLA-DR Antigens
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Aged80
Country/Region as subject:
Asia
Language:
English
Year:
2006
Type:
Article
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