Does addition of lidocaine to medium- and long-chain triglyceride propofol emulsions significantly reduce pain on injection?
Article
in English
| IMSEAR
| ID: sea-42905
ABSTRACT
BACKGROUND:
Propofol formulated with medium- and long-chain triglycerides (MCT/LCT) causes less pain on injection than standard Propofol, but the incidence of pain persists between 28 and 67 percent. Such a broad range begs the question so the authors wanted to clarify whether the addition of lidocaine to medium- and long-chain triglyceride emulsion propofol results in any clinically significant lessening of pain on injection. The authors conducted a randomized, prospective, double-blinded study to compare the injection pain felt following the administration of propofol-MCT/LCT (Propofol-Lipuro) to propofol-MCT/LCT plus 20 mg lidocaine for the induction of anesthesia. MATERIAL ANDMETHOD:
The present study included 270 non-premedicated ASA I-II adult patients scheduledfor elective surgery under general anesthesia. Patients were allocated randomly into two groups to receive either propofol-MCT/LCT alone or propofol-MCT/LCT plus 20 mg lidocaine. The study solution was injected at 1 mL/second by one anesthesiologist and patients graded any associated pain using a four-point scale.RESULTS:
The overall incidence of pain on injection was 31/133 (23%) in the propofol-MCT/LCT plus lidocaine group vs. 45/135 (33%) in the propofol-MCT/LCT alone group. The difference in the incidence of pain on injection between groups failed to achieve statistical significance (p = 0.23) and no significant difference in intensity of pain between the two study groups occurredCONCLUSIONS:
The authors concluded that the addition of lidocaine (20 mg) to the propofol-MCT/LCT does not significantly reduce the incidence or severity of the pain on injection.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain
/
Triglycerides
/
Female
/
Humans
/
Male
/
Propofol
/
Double-Blind Method
/
Incidence
/
Risk Factors
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Anesthetics, Intravenous
Type of study:
Controlled clinical trial
/
Etiology study
/
Incidence study
/
Prognostic study
/
Risk factors
Language:
English
Year:
2008
Type:
Article
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