Efficacy and safety of bimatoprost for the treatment of open-angle glaucoma and ocular hypertension: a three-month, open-label study in community-based practices in Thailand.
Article
in English
| IMSEAR
| ID: sea-43202
ABSTRACT
The authors evaluated the effectiveness and safety of bimatoprost using an open-label, non-comparative, three-month, community-based surveillance study. Patients (n = 458) with open-angle glaucoma or ocular hypertension received bimatoprost 0.03% ophthalmic solution as monotherapy, replacement therapy or adjunctive therapy. Bimatoprost produced a rapid, significant (p < 0.0001) reduction in intraocular pressure monotherapy (34.6% reduction), replacement therapy (16.4% reduction); adjunctive therapy (24.1% reduction). Bimatoprost enabled more patients to achieve their pre-defined target intraocular pressure (p < 0.0001), compared to previous treatments, and significantly lowered intraocular pressure, regardless of the patients' baseline pressure level or history of pressure control. Bimatoprost was well-tolerated; the most commonly reported adverse event was conjunctival hyperaemia (19.9%). Most patients and ophthalmologists rated bimatoprost highly, compared to previously used treatments. The authors concluded that bimatoprost is an effective, well-tolerated treatment for lowering intraocular pressure in Thai patients with open-angle glaucoma or ocular hypertension.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ophthalmic Solutions
/
Safety
/
Thailand
/
Female
/
Humans
/
Male
/
Glaucoma, Open-Angle
/
Ocular Hypertension
/
Population Surveillance
/
Treatment Outcome
Type of study:
Controlled clinical trial
/
Screening study
Country/Region as subject:
Asia
Language:
English
Year:
2005
Type:
Article
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