Dysplastic nodules and small primary carcinoma of the liver: a study detecting the early morphological changes during hepatocarcinogenesis.
Article
in English
| IMSEAR
| ID: sea-43360
ABSTRACT
OBJECTIVE:
Detect the early histological changes relating to human hepatocarcinogenesis in three nodular hepatocellular lesions. MATERIAL ANDMETHOD:
Three cases of dysplastic nodules and one of small hepatocellular carcinoma were obtained from the authors' surgical-pathology file during 2000-2005 for a histopathological study in relevance to the early changes during hepatocarcinogenesis by employing hematoxylin and eosin stain, as well as some immunohistochemical staining.RESULTS:
One nodular hepatocellular lesion, diagnosed as a complex lesion of focal nodular hyperplasia contained a microscopic focus (1.5 mm in diameter) of combined hepatocellular and cholangiocarcinoma.CONCLUSION:
The small dysplastic hepatocytes subjected to neoplastic transformation combined hepatocellular and cholangiocarcinoma and are the precursorial cells of hepatocellular carcinoma. Chronic viral hepatitis B or C, aflatoxin B, and nitrosamine(s), as well as some nodular hepatocellular lesions share distinct roles in the complex process of hepatocarcinogenesis pertaining to this Southeast Asian country.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Time Factors
/
Female
/
Humans
/
Male
/
Retrospective Studies
/
Adult
/
Hepatocytes
/
Early Diagnosis
/
Liver Neoplasms
/
Middle Aged
Type of study:
Diagnostic study
/
Observational study
/
Screening study
Language:
English
Year:
2007
Type:
Article
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