Detection of JC virus infection in progressive multifocal leukoencephalopathy: the first documented case in Thailand.
Article
in English
| IMSEAR
| ID: sea-44363
ABSTRACT
Progressive Multifocal Leukoencephalopathy (PML) is a demyelinating brain disease caused by human polyoma JC virus (JCV). This disease is an important cause of morbidity and mortality in AIDS patients. Definite diagnosis currently requires a brain biopsy. PCR for JCV of CSF, an emerging diagnostic tool, has a high specificity for the diagnosis of PML in patients with characteristics on clinical and neuroradiological findings. The authors report a 36-year-old woman who presented with prolonged fever, progressive weakness, and slow speech for 2 months. Clinical features and MRI findings were compatible with PML. Qualitative PCR for JCV of CSF showed a positive result. This report emphasizes the yield of PCR, the CSF for JCV in a diagnosis of PML, which may reduce the need for a brain biopsy in such cases.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Antiviral Agents
/
Thailand
/
Biopsy
/
Female
/
Humans
/
Polymerase Chain Reaction
/
Acquired Immunodeficiency Syndrome
/
Leukoencephalopathy, Progressive Multifocal
/
Treatment Outcome
/
JC Virus
Type of study:
Diagnostic study
/
Qualitative research
Country/Region as subject:
Asia
Language:
English
Year:
2002
Type:
Article
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