Reference value for urinary deoxypyridinoline as a specific marker for measuring bone resorption in Thais.
Article
in English
| IMSEAR
| ID: sea-44401
ABSTRACT
In the next century, the increasing number of elderly and rising healthcare costs will bring with it metabolic bone problems, particularly osteoporosis. Deoxypyridinoline Dpd in urine is a sensitive and specific marker for screening and monitoring of bone resorption in a variety of diseases affecting bone turnover and in risk groups especially in the postmenopause. The reference value among aging (21-60 years) of a healthy well defined group was studied by collecting the urine between 700-1000 hours and using the ELISA technique to determine the level of Dpd. The reference value of Dpd in 113 males and 298 females 1.3-6.5 and 1.5-6.9 nm Dpd/nm Creatinine respectively. The level of Dpd in females was significantly higher than in males at p < 0.028. However, the average value of deoxypyridinoline in postmenopause was higher than premenopause but not different at p = 0.05. There are many factors which influence the results so the overall reference value is only a guideline for screening in bone resorption.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Reference Values
/
Thailand
/
Bone Resorption
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Female
/
Humans
/
Male
/
Biomarkers
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Adult
/
Amino Acids
/
Middle Aged
Country/Region as subject:
Asia
Language:
English
Year:
1999
Type:
Article
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