Multi-drug resistant HIV-1 reverse transcriptase genotype in children treated with dual nucleoside reverse transcriptase inhibitors (NRTIs).
Article
in English
| IMSEAR
| ID: sea-44418
ABSTRACT
BACKGROUND:
Multi-drug resistant HIV mutants have been reported after prolonged dual antiretroviral therapy.OBJECTIVE:
To evaluate the prevalence and resistance pattern in HIV-infected children treated with dual NRTIs. MATERIAL ANDMETHOD:
Records of HIV-infected children treated with dual NRTIs at Srinagarind Hospital, Khon Kaen University, Thailand, were reviewed for baseline data and their consensually-stored plasma were checked for the occurrence of HIV mutants by genotyping.RESULTS:
Fifty-seven HIV-infected children were treated with dual NRTI regimens (27 males; 30 females). The median age and median CD4+ T-lymphocyte at genotypic testing were 83.5 months and 10.9%, respectively. The median duration of ARV therapy was 22 months. More than half the children (42) were on zidovudine and didanosine. A set of three or more nucleoside analog mutations (NAMs), conferring multi-dideoxynucleoside resistance, was found in 60% of the cases.CONCLUSION:
High percentages of NAMs were found in HIV-infected children previously on dual ARV therapy for long periods. Genotypic testing was helpful in designing the second antiretroviral regimen.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thailand
/
Female
/
Humans
/
Male
/
HIV Infections
/
Child
/
HIV-1
/
Reverse Transcriptase Inhibitors
/
Anti-HIV Agents
/
Drug Resistance, Multiple, Viral
Country/Region as subject:
Asia
Language:
English
Year:
2006
Type:
Article
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