Anticoagulation protocol and early prosthetic valve thrombosis.
Indian Heart J
;
2004 May-Jun; 56(3): 225-8
Article
in English
| IMSEAR
| ID: sea-4461
ABSTRACT
BACKGROUND:
[corrected] Prosthetic valve thrombosis is a major cause of morbidity and mortality following heart valve replacement with a mechanical valve. METHODS ANDRESULTS:
538 patients who underwent mechanical valve replacement between April 1999 and June 2003 were included in the study. They were divided into two groups. Group A (n=245) consisted of patients who underwent mechanical valve replacement between April 1999 and June 2001. Anticoagulation was started on the first post-operative day and consisted of only oral nicoumalone. Group B (n=293) consisted of patients who underwent mechanical valve replacement between July 2001 and June 2003; enoxaparin was started six hours following surgery in addition to oral nicoumalone which was started on first post-operative day. Fifteen (6.1%) patients in group A developed early prosthetic valve thrombosis at an interval of 4.33+/-0.97 months (range 3-6 months) following surgery. Ten had prosthetic valve thrombosis in the mitral position and five had prosthetic valve thrombosis in the aortic position. In group B, six (2.1%) patients developed early prosthetic valve thrombosis at a median interval of 4.58+/-0.9 months (range 3.5-6 months) in the mitral position (p=0.01).CONCLUSIONS:
Addition of enoxaparin to the anticoagulation regime in the immediate post-operative period significantly reduces early prosthetic valve thrombosis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Postoperative Complications
/
Thrombosis
/
Female
/
Humans
/
Male
/
Heart Valve Prosthesis
/
Follow-Up Studies
/
Adolescent
/
Treatment Outcome
/
Enoxaparin
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Indian heart j
Year:
2004
Type:
Article
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