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Performance of the Khon Kaen Osteoporosis Study (KKOS) score for identifying osteoporosis in men.
Article in English | IMSEAR | ID: sea-44622
ABSTRACT

OBJECTIVE:

The present study evaluated the diagnostic performance of Khon Kaen Osteoporosis Study (KKOS) score in identifying osteoporosis in men. MATERIAL AND

METHOD:

This was a cross-sectional investigation in 230 men aged > or = 50 years. Bone mineral density (BMD) was measured at the femoral neck and lumbar spine by DXA (DPX-IQ densitometer LUNAR Corporation, Madison, Wisconsin, USA). The KKOS score was calculated for each man using his age and weight. Men with KKOS scores < or = -1 and > -1 were classified as "high risk" and "low risk", respectively.

RESULTS:

The prevalence of osteoporosis in the entire sample was 17% and 7.4% (n = 39, 17) by femoral neck BMD and lumbar spine BMD, respectively. Using the KKOS score, 80 (34.8%) men were classified as "high risk" (KKOS score < or = -1). The proportion of high risk individuals increased with advancing age, ranging from 16.2% in the 50-65 age group to 64.8% in the > 65 age group. Using BMD from DXA as a gold standard, the overall sensitivity and specificity of KKOS in identifying osteoporosis was 72.5% and 73.2%, respectively. However; the sensitivity was higher at the lumbar spine (94.1% vs. 71.8%) than the femoral neck, while the specificity was comparable. The PPV of KKOS was 36%; and was lower at the lumbar spine (20%) compared to the femoral neck (35%). In the present study, men were classified "high risk" from KKOS, the risk (odds ratio; OR) of osteoporosis at the femoral neck and/or lumbar spine was 7.19 (95% CI 3.34-15.44). However, the risk of osteoporosis was higher in the younger age (50-65 yr) group (OR 10.29, 95% CI 3.31-31.94) compared with the older age (> 65 yr) group (OR 3.65, 95% CI 1.12-11.91).

CONCLUSION:

KKOS scoring system based on age and body weight, is a simple tool for clinicians to make a decision to further DXA testing for identifying osteoporosis in Thai men. This tool had a high sensitivity and specificity, but modest PPV.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Osteoporosis / Thailand / Body Weight / Aged, 80 and over / Aged / Humans / Male / Bone Density / Risk Factors / Sensitivity and Specificity Type of study: Diagnostic study / Etiology study / Prognostic study / Risk factors Limits: Aged80 Country/Region as subject: Asia Language: English Year: 2007 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Osteoporosis / Thailand / Body Weight / Aged, 80 and over / Aged / Humans / Male / Bone Density / Risk Factors / Sensitivity and Specificity Type of study: Diagnostic study / Etiology study / Prognostic study / Risk factors Limits: Aged80 Country/Region as subject: Asia Language: English Year: 2007 Type: Article