Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level.
Article
in English
| IMSEAR
| ID: sea-44767
ABSTRACT
BACKGROUND:
The active substance found in Capsicum frutescens (capsicum) that gives hot and spicy flavor is capsaicin, and it seems to have many pharmacological effects.OBJECTIVE:
The present research was conducted to study the effect of capsicum on plasma glucose level and to correlate its action with the pharmacokinetic properties of capsaicin in capsicum. MATERIAL ANDMETHOD:
The crossover study was performed in 12 healthy volunteers by performing the OGTT while receiving placebo or 5 grams of capsicum. The insulin secretion and capsaicin level in plasma were measured using the HPLC method.RESULTS:
The results of the OGTT showed that plasma glucose levels in volunteers who received capsicum were significantly lower than those in the placebo group at 30 and 45 minutes (p < 0.05). Furthermore, plasma insulin levels were significantly higher at 60, 75, 105, and 120 minutes (p < 0.05). When comparing before and after capsicum intake, the results showed the insulin levels were maintained The pharmacokinetic parameters of capsaicin shown as C(max), T(max), AUC(0-t), T1/2 are 2.47 +/- 0.13 ng/ml, 47.08 +/- 1.99 min, 103.6 +/- 11.3 ng x min/ml, and 24.87 +/- 4.97 min, respectively.CONCLUSION:
In conclusion, the present study found that 5 grams of capsicum presented capsaicin levels that were associated with a decrease in plasma glucose levels and the maintenance of insulin levels. The present result might have clinical implications in the management of type 2 diabetes.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Blood Glucose
/
Humans
/
Male
/
Plant Extracts
/
Capsaicin
/
Analysis of Variance
/
Cross-Over Studies
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Adult
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Area Under Curve
/
Fruit
Type of study:
Controlled clinical trial
/
Prognostic study
Language:
English
Year:
2009
Type:
Article
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