Very high dose phenobarbital for refractory status epilepticus.
Article
in English
| IMSEAR
| ID: sea-44916
ABSTRACT
BACKGROUND:
Refractory status epilepticus (RSE), defined as status epilepticus that fails to respond to first, second and third-line therapy. The RSE is associated with high morbidity and mortality. Treatment guidelines of RSE give a spectrum of options, such as, continuous intravenous (i.v.) midazolam (MDL), or continuous i.v. propofol (PRO) as alternatives to phenobarbital (PB) or continuous i.v. pentobarbital (PTB).OBJECTIVE:
To study the efficacy of very-high-dose phenobarbital (VHDPB) for treatment RSE. STUDYDESIGN:
Retrospective study MATERIAL ANDMETHOD:
The authors collected and analyzed data from adult patients who were diagnosed with RSE.RESULTS:
The authors present 10 patients with RSE who were treated with VHDPB. All of them were generalized convulsive status epilepticus (GCSE). Ages ranged from 16-86 years old (mean. 43 years). PB dosage ranged 40-140 mg/kg/day (mean 70 mg/kg/day). The duration of status epilepticus (SE) varied widely, ranged 1-44 days (mean 7 days). PB level ranged 35.29-218.34 ug/mL (mean 88.1 ug/mL). RSE was controlled by VHDPB 70%, 30% were not controlled.ConclusioN:
VHDPB were considered as alternative treatment for RSE.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phenobarbital
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Recurrence
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Status Epilepticus
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Aged, 80 and over
/
Aged
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Female
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Humans
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Male
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Retrospective Studies
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Adolescent
Type of study:
Practice guideline
/
Observational study
Limits:
Aged80
Language:
English
Year:
2007
Type:
Article
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