Incidence and risk factors of nevirapine-associated severe hepatitis among HIV-infected patients with CD4 cell counts less than 250 cells/microL.
Article
in English
| IMSEAR
| ID: sea-44920
ABSTRACT
OBJECTIVES:
To determine incidence and risk factors of nevirapine (NVP)-associated severe hepatitis that led to NVP discontinuation among HIV-infected patients with CD4 < 250 cells/microL. MATERIAL ANDMETHOD:
A retrospective cohort study was conducted among antiretroviral-naïve HIV-infected patients who had baseline CD4 < 250 cells/microL and were initiated NVP-based antiretroviral therapy (ART) between January 2003 and October 2005. All patients were categorized to group A occurred clinical hepatitis and group B did not occur clinical hepatitis. All were followed until 6 months after ART.RESULTS:
There were 910 patients with a mean age of 35.4 years, 57% were males and median (IQR) CD4 cell count was 27 (9-80) cells/microL; contributing 5,006 person-months of observations. Ten (1.1%) patients were in group A and 900 (98.9%) patients were in group B. Incidence of clinical hepatitis was 2 per 1,000 person-months. Probabilities of clinical hepatitis at 0.5, 1, 2, 3 and 6 months after ART were 0.2%, 0.5%, 0.7%, 0.8% and 1.1%, respectively. By Cox regression analysis, baseline AST > or = 1.5 times of upper limit was associated with higher incidence of clinical hepatitis (p = 0.019, HR = 5.83, 95% CI = 1.33-25.51).CONCLUSION:
Incidence of NVP-associated severe hepatitis that lead to NVP discontinuation among HIV-infected patients with baseline CD4 < 250 cells/microL is low. The higher baseline AST is also associated with a higher risk of severe hepatitis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aspartate Aminotransferases
/
Female
/
Humans
/
Male
/
HIV Infections
/
Incidence
/
Retrospective Studies
/
Risk Factors
/
Sickness Impact Profile
/
CD4 Lymphocyte Count
Type of study:
Etiology study
/
Incidence study
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Observational study
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Prognostic study
/
Risk factors
Language:
English
Year:
2008
Type:
Article
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