Outcomes of pregnancies complicated by systemic lupus erythematosus (SLE).
Article
in English
| IMSEAR
| ID: sea-44950
ABSTRACT
OBJECTIVE:
To assess the outcomes of pregnancies complicated by systemic lupus erythematosus (SLE) and evaluate the clinical course of the disease during pregnancy. MATERIAL ANDMETHOD:
The database of high-risk pregnancies between 1995 and 2006 was prospectively collected and searched for pregnancies with SLE. The medical records were reviewedRESULTS:
Sixty-eight pregnant women were identified during the period of the present study. Of 61 (89.7%) live births, 27 (39.7%) had preterm delivery and 20 (29.4%) had fetal growth restriction. Mean gestational age was 35.6 +/- 4.2 weeks. Mean neonatal birth weight was 2322 +/- 781 grams. There were seven (10.3%) perinatal deaths. Maternal SLE flares occurred in 20 (29.4%), seven in the first trimester, eight in the second trimester five in the third trimester, and none in the post partum period. Preeclampsia is the most common maternal complication (20.6%). There was a higher rate of flares if the pregnancy occurred while the disease was active. The predictor of poor pregnancies outcomes included flare-up of the disease, renal involvement, hypertension, and conception while the disease is active.CONCLUSION:
Active SLE prior to pregnancy is associated with a less favorable maternal and fetal outcome. Hypertension increased the risk of fetal loss and adverse outcome.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pregnancy Complications
/
Birth Weight
/
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
/
Pregnancy Outcome
/
Infant Mortality
/
Prospective Studies
/
Risk Factors
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Year:
2007
Type:
Article
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