An evaluation of glycosylated hemoglobin measurement by a colorimetric method as a screening test for gestational diabetes mellitus.
Article
in English
| IMSEAR
| ID: sea-45235
ABSTRACT
To assess the potential value of glycosylated hemoglobin measurement (HbA1) in screening for gestational diabetes mellitus (GDM), HbA1 by a colorimetric method, plasma glucose level 1 hr after 50 g oral glucose loading, and 3-hr 100 g oral glucose tolerance test (3-hr OGTT) were performed in 334 pregnant women at Ramathibodi Hospital. These subjects carried high risk factors of GDM. Gestational ages varied from 24 to 38 wks. Twenty-four cases were diabetic (7.2%) by O'Sullivan and Mahan's criteria (1964). As a screening test to select subjects for 3-hr OGTT, plasma glucose level 1 hr after 50 g oral glucose load (plasma glucose level 7.8 mmol/L and above) has sensitivity 87.50 per cent, specificity 64.19 per cent. HbA1 level of 5.60 per cent (upper 95% confidence limit of the mean) and above yield sensitivity 66.67 per cent, specificity 61.29 per cent. Thus, glycosylated hemoglobin measurement as a screening test for GDM is not as effective as the conventional 50 g oral glucose loading test.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pregnancy in Diabetics
/
Prenatal Care
/
Thiobarbiturates
/
Female
/
Humans
/
Glycated Hemoglobin
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Infant, Newborn
/
Pregnancy
/
Mass Screening
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Predictive Value of Tests
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Language:
English
Year:
1993
Type:
Article
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