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Lipid peroxidation and renal injury in renal ischemic reperfusion: effect ofangiotensin inhibition.
Article in English | IMSEAR | ID: sea-45366
ABSTRACT

OBJECTIVES:

To investigate the role of angiotensin inhibition on lipid peroxidation (LPO) and renal pathology in ischemic reperfusion (IR). MATERIAL AND

METHOD:

Male Wistar rats were subjected to 15-, 30-, 45- or 60- minutes ofrenal ischemia (I) by left renal artery occlusion. In the 30-minute I group, reperfusion (R) for I day (13,R) was performed in additional animals that had been treated with water, angiotensin converting enzyme inhibitor (ACE]; enalapril 5 mg/kg/d), or angiotensin receptor type 1 blocker (ARB; losartan 10 mg/kg/d) one day before I and were continued for 1 day after R. Renal tissue malondialdehyde (MDA), an indicator of LPO, was examined during I and IR periods. Renal pathology was also determined.

RESULTS:

During ischemia, renal tissue MDA levels were increased throughout the 60-minute ischemic period and was maximum at 30 minutes of ischemia (p < 0.01). Histological changes in 30-minutes I group showed slight tubular cell congestion and mild interstitial edema. One day after reperfusion, MDA levels were still elevated (p < 0. 01) when compared with sham. Progression of renal pathology was observed after I day of reperfusion. Both ACEI and ARB could attenuate the heightened MDA levels (p < 0.01). IR-induced renal injury was markedly diminished by administration ofACEI as well as by ARB.

CONCLUSION:

These results indicate that inhibition of angiotensin could reduce lipid peroxidation and ameliorate renal injury during IR condition.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Male / Angiotensin I / Lipid Peroxidation / Reperfusion Injury / Rats, Wistar / Kidney / Animals Language: English Year: 2006 Type: Article
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Male / Angiotensin I / Lipid Peroxidation / Reperfusion Injury / Rats, Wistar / Kidney / Animals Language: English Year: 2006 Type: Article