Evaluation of endometrial changes and p53 expression in tamoxifen treated women: comparison of various methods.
Article
in English
| IMSEAR
| ID: sea-46437
ABSTRACT
OBJECTIVE:
To compare transvaginal sonography (TVS), sonohysterography (SHG), hysteroscopy and endometrial aspiration (EA) and p53 expression in assessing endometrial abnormalities in women on tamoxifen.METHODS:
In a cross sectional study of 50 pre- and post-menopausal women receiving tamoxifen for > 2 years, all participants underwent TVS and EA. Those with endometrial thickness > 4 mm on TVS underwent hysteroscopy and SHG. Serum p53 antibody and p53 immunohistochemistry were tested in all women.RESULTS:
The sensitivity and specificity when compared with histopathology as the reference standard were as follows TVS 100% and 33.3%, SHG 85.7% and 50%, hysteroscopy 92.8% and 80.8%, serum p53 50% and 83.3%, and p53 immunohistochemistry 57.1% and 61.1%. Prevalence of endometrial abnormalities was not significantly different in asymptomatic and symptomatic women.CONCLUSION:
Tamoxifen-users require routine testing for endometrial evaluation. TVS followed by hysteroscopy and biopsy is an effective option. p53 expression correlates with histological abnormalities.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Tamoxifen
/
Breast Neoplasms
/
Aged
/
Female
/
Humans
/
Hysteroscopy
/
Cross-Sectional Studies
/
Antineoplastic Agents, Hormonal
/
Adult
/
Endometrium
Type of study:
Evaluation studies
/
Observational study
/
Prevalence study
/
Risk factors
Language:
English
Year:
2006
Type:
Article
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