Effectiveness of nicotinic acid and bezafibrate alone and in combination for reducing serum triglyceride level.
Article
in English
| IMSEAR
| ID: sea-46504
ABSTRACT
OBJECTIVE:
To study the effectiveness of nicotinic acid and Bezafibrate alone and in combination for reducing triglyceride level.DESIGN:
It was a randomised, prospective, longitudinal study.SETTING:
Patients attending a private clinic, and medical department of Kathmandu Medical College, Sinamangal.METHODS:
This study included 83 consecutive patients, 19 females and 64 males with hypertriglyceridaemia (defined as serum triglyceride >200mg/dl) attending the department of medicine, Kathmandu Medical College, Sinamangal and private clinic. MAIN OUTCOMEMEASURES:
Statistically significant reduction of serum triglyceride level.RESULT:
51 out of 83 patients completed the study in which Nicotinic acid alone reduced the serum trygleceride level from 320.62 +/- 104.23 to 182.55 +/- 46.21, which is a reduction of 138.07 +/- 85.69 (P. value = 001). Bezafibrate when given alone also reduced triglyceride level significantly from 345.25 +/- 181.03 to 203.30+/-93.59 which is a reduction of 141.95 +/- 121.130 (P value= .001). When a combination of both drugs was given the reduction of 472.73+/-247.53 (P value =.002) was achieved.CONCLUSIONS:
Nicotinic acid is a very effective drug in reducing serum triglyceride level and its effectiveness is similar to Bezafibrate. There is no added benefit of giving a combination of nicotinic acid and Bezafibrate in reducing serum triglyceride level.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Triglycerides
/
Bezafibrate
/
Female
/
Humans
/
Male
/
Hypertriglyceridemia
/
Treatment Outcome
/
Drug Therapy, Combination
/
Hypolipidemic Agents
/
Niacin
Type of study:
Controlled clinical trial
/
Observational study
Language:
English
Year:
2005
Type:
Article
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