Evaluation of anti-inflammatory activity of Calotropis gigantea (AKANDA) in various biological system.
Article
in English
| IMSEAR
| ID: sea-46802
ABSTRACT
To evaluate the effect of Calotropis G in various experimental animal models. The anti-inflammatory activity was evaluated using carrageenin-induced kaolin -induced rat paw oedema for acute and cotton-pellet granuloma, adjuvant-induced arthritis model for chronic inflammation. Antipyretic activity was carried out using yeast induced pyresis method. Phenylquinone--induced writhing method in mice was used for analgesic activity. Test compounds exhibited variable anti-inflammatory activity and peak activity of the test compounds were reached at 2 h. Alkaloid fraction possesses comparatively high initial anti-inflammatory activity. The residual anti-inflammatory activity of alkaloid fraction of Calotropis G suggest either a greater protein binding nature of the compound there by providing a slow released pool of active drug molecule in the system or non available of possible bioactive metabolites to retain the activity profile relation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Arthritis, Experimental
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Rats
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Male
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Plant Extracts
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Phenylbutazone
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Chronic Disease
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Models, Animal
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Calotropis
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Edema
/
Homeopathy
Type of study:
Prognostic study
Language:
English
Year:
2006
Type:
Article
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