The efficacy of three anthelmintic drugs given in a single dose.
Ceylon Med J
;
1996 Jun; 41(2): 42-5
Article
in English
| IMSEAR
| ID: sea-47378
ABSTRACT
OBJECTIVE:
To compare the efficacy of a single dose mebendazole 500 mg from the original manufacturer and a formulation locally produced by State Pharmaceuticals Manufacturing Corporation of Sri Lanka and albendazole 400 mg in mass treatment of soil-transmitted nematode infections.DESIGN:
Randomised trial.SETTING:
Government owned plantations in low-country regions of Sri Lanka with poor sanitary facilities.SUBJECTS:
399 children 3 to 15 years of age infected with at least one type soil-transmitted nematode. INTERVENTION Mebendazole 500 mg or albendazole 400 mg given as single dose treatment. MEASUREMENTS Cure rates and egg reduction rates calculated from egg counts of pre- and post-treatment stool samples using the quantitative Kato-Katz technique.RESULTS:
All three drugs were effective against Ascaris infection with cure rates above 95%. The efficacy against Trichuris trichuria was uniformly poor. For hookworm infection albendazole appeared to be more effective in a single dose with cure rates of 77.9% compared with 28.7% and 35.8% for the two mebendazole formulations; corresponding egg reduction rates were 95.4% compared with 72.0% and 74.5%.CONCLUSION:
Albendazole is the drug of choice for mass deworming where hookworm disease is prominent. There was no statistically significant difference between the original and locally produced mebendazole.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Soil
/
Humans
/
Albendazole
/
Child
/
Child, Preschool
/
Adolescent
/
Treatment Outcome
/
Mebendazole
/
Anthelmintics
/
Nematode Infections
Type of study:
Controlled clinical trial
Language:
English
Journal:
Ceylon Med J
Year:
1996
Type:
Article
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