Macrovascular disease in Sri Lankan kidney transplant recipients.
Ceylon Med J
;
1997 Jun; 42(2): 78-80
Article
in English
| IMSEAR
| ID: sea-47555
ABSTRACT
INTRODUCTION:
Macrovascular diseases such as angina, myocardial infarction, stroke and peripheral occlusive arterial disease are common causes of mortality and morbidity in transplant patients.OBJECTIVES:
To study the frequency and determinants if vascular disease in Sri Lankan patients with renal transplants. PATIENTS A cohort of 237 renal transplant recipients (163 males (76%), mean age 35.09, SD 11.05 years).SETTING:
Patients under follow up at the Faculty of Medicine Transplant program.METHOD:
Prospective study of a cohort of patients.RESULTS:
Macrovascular diseases developed in 42% of transplant recipients. 5.6% had transient ischaemic attacks, 2.8% strokes, 18.2% angina, 8.4% myocardial infarctions, 2.3% underwent lower extremity amputations because of vascular insufficiency, 7% peripheral vascular occlusive disease and 49.5% were hypertensive. Male sex (odds ratio of 2.87, 95% CI 1.33-6.85, p = 0.006), serum cholesterol greater than 6.2 mmol/l at transplant (odds ratio 8.60, 95% CI 2.53-38.9, p = 0.0001) at 5 years after transplant (odds ratio 10.25, 95% CI 1.22-22.9, p = 0.01) were associated with a higher risk of macrovascular disease. Pre-transplant diabetes was associated with a higher risk of macrovascular disease and lower extremity amputation (odds ratio 4.53, 95% CI 1.32-6.76, p = 0.007).CONCLUSIONS:
Strategies to screen for and treat potential risk factors should form an integral part of the follow up for Sri Lankan and Asian kidney transplant recipients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Postoperative Complications
/
Sri Lanka
/
Female
/
Humans
/
Male
/
Cardiovascular Diseases
/
Prospective Studies
/
Risk Factors
/
Kidney Transplantation
/
Adult
Type of study:
Etiology study
/
Observational study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Ceylon Med J
Year:
1997
Type:
Article
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