Plasma pharmacokinetics of a generic amoxycillin and the innovator brand: a comparison.
Ceylon Med J
;
1998 Mar; 43(1): 16-8
Article
in English
| IMSEAR
| ID: sea-48191
ABSTRACT
OBJECTIVE:
To compare the bioavailability and plasma pharmacokinetics of a generic brand of amoxycillin (State Pharmaceutical Manufacturing Coporation) selected from the lower price range, with that of the innovation brand (Amoxil, Beecham).DESIGN:
Sixteen healthy adult volunteers were allotted to two groups and each group was given a test dose of amoxycillin from each brand. Blood samples were collected at 0, 2, 3 and 4 hours thereafter plasma levels were assayed using high performance liquid chromatography.RESULTS:
Analysis of results show that the generic product had similar bioavailability and pharmacokinetics when compared with the innovator product.CONCLUSION:
The quality assured generic amoxycillin tested had similar bioavailability as a more costly branded version.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Penicillins
/
Reference Values
/
Female
/
Humans
/
Male
/
Biological Availability
/
Administration, Oral
/
Chromatography, High Pressure Liquid
/
Adolescent
/
Drugs, Generic
Type of study:
Prognostic study
Language:
English
Journal:
Ceylon Med J
Year:
1998
Type:
Article
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