Efficacy of a single dose treatment of Wuchereria bancrofti microfilaria carriers with diethylcarbamazine in Matara, Sri Lanka.
Ceylon Med J
;
1998 Sep; 43(3): 151-5
Article
in English
| IMSEAR
| ID: sea-48242
ABSTRACT
OBJECTIVE:
To test the efficacy of diethylcarbamazine DEC single dose regimen of 6 mg/kg body weight (bw) on a sample of Wuchereria bancrofti microfilaria (mf) carriers in Matara.DESIGN:
6 mg/kg bw DEC dose in 50 mg tablets given under direct observation to the subjects at 23.00 hours after pre-treatment blood collection for mf counts. Post-treatment mf counts were at 1, 2 weeks and 1, 3, 6, 12 months.SUBJECTS:
31 asymptomatic mf carriers, 14 males, age range 6 to 62 years.RESULTS:
Treatment resulted in 89 to 97% success rate, 19 to 28% cure rates and 74 to 80% reduction in mf density. There was no difference statistically in the success rate and cure rate at 6 and 12 months. The effect of DEC treatment at 6 and 12 months compared by sex, age group and pre-treatment mf level showed no difference. 64.5% of the carriers treated had at least one mild adverse reaction. Rates of the common reactions were 41.9% fever, 22.6% headache and 16.1% joint pains.CONCLUSION:
A new mass treatment program has been initiated by the national Antifilariasis Campaign using the single dose DEC 6 mg/kg bw regimen. The satisfactory reduction in mf density at 6 and 12 months following DEC single dose treatment we observed provides support for this program.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Wuchereria bancrofti
/
Elephantiasis, Filarial
/
Female
/
Humans
/
Male
/
Carrier State
/
Child
/
Adolescent
/
Treatment Outcome
/
Adult
Language:
English
Journal:
Ceylon Med J
Year:
1998
Type:
Article
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