Anti-idiotype antibodies and circulating immune complexes after immunisation with tetanus-toxoid.
Ceylon Med J
;
1994 Jun; 39(2): 97-100
Article
in English
| IMSEAR
| ID: sea-48389
ABSTRACT
OBJECTIVES:
To determine if anti-idiotype antibodies and circulating immune complexes in individuals before and after immunisation with tetanus toxoid play a role in the immune response.DESIGN:
A study of individuals who were administered a single dose of tetanus toxoid (TT) and who were unimmunized.SETTING:
Out patient departments of a large public hospital in Bombay, India.SUBJECTS:
Thirty eight individuals pre-immunisation and forty five individuals post-immunisation with tetanus toxoid, tested at 1, 3, 6, and 12 months. MAIN OUTCOMEMEASURE:
Development of anti-tetanus anti-idiotype antibodies and circulating immune complexes.RESULTS:
Pre-immunisation cases did show presence of anti-tetanus antibodies but in lower titres than post-immunisation up to six months, after which there was a reduction. Specific anti-idiotype antibodies were detected in 19 cases. One and three months after immunisation more cases had high titre antibodies and circulating immune complexes, though after six months, there was a fall in anti-tetanus antibody titres. Circulating immune complexes were seen in those samples having anti-idiotype antibodies.CONCLUSIONS:
Though a significant rise in anti-tetanus antibody anti-idiotype antibodies, protective levels in mice and circulating immune complexes are seen after immunisation with TT it lasts for six months. When followed up for a period of one year it is observed that in cases having auto anti-idiotype antibodies, the anti-tetanus antibodies are maintained for a longer period.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Immunoglobulin G
/
Tetanus Toxoid
/
Antibodies, Anti-Idiotypic
/
Immunization
/
Immune Tolerance
/
Antibodies, Bacterial
/
Antigen-Antibody Complex
Language:
English
Journal:
Ceylon Med J
Year:
1994
Type:
Article
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