Anti-tuberculosis drug inducd hepatitis - a Sri Lankan experience.
Ceylon Med J
;
2006 Mar; 51(1): 9-14
Article
in English
| IMSEAR
| ID: sea-48708
ABSTRACT
OBJECTIVE:
To assess the incidence of anti-tuberculosis (TB) drug induced hepatitis (AIH) in Sri Lankan patients, determine risk factors of AIH, and to address management options in AIH.DESIGN:
A prospective study.SETTING:
Chest Hospital, Welisara, Sri Lanka, from April 2001 to April 2002. PATIENTS Seven hundred and eighty three patients with a confirmed diagnosis of TB and resident in the Colombo and Gampaha districts who presented to Chest Hospital, Welisara, Sri Lanka.METHODS:
WHO recommended treatment was commenced in all cases. AIH was diagnosed when patients complained of decreased appetite with nausea or vomiting and elevated serum bilirubin (SB; >1.1 mg/dL) or elevated serum alanine transferase (ALT; > 3 times upper limit of normal).RESULTS:
Of 783 enrolled patients, 74 (9.5%) developed AIH, the majority (58%) developing AIH within the first 2 weeks of the intensive phase of treatment. AIH was more common among patients over 60 years (p = 0.018), who developed pulmonary TB (p = 0.028), and in patients weighing 33-55 kg (p = 0.004). Age, weight and rifampicin overdosage were significant predictors of AIH. Of the 74 AIH patients, standard treatment was restarted in 60, treatment modified in six, two defaulted and six died.CONCLUSIONS:
The incidence of AIH in Sri Lanka is 9.5% in treated patients. AIH was associated with age, low body weight and rifampicin overdosage.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rifampin
/
Sri Lanka
/
Tuberculosis
/
Female
/
Humans
/
Male
/
Streptomycin
/
Child
/
Incidence
/
Prospective Studies
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Ceylon Med J
Year:
2006
Type:
Article
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