Long term use of thalidomide: safe and effective.
Indian J Cancer
;
2007 Jul-Sep; 44(3): 108-10
Article
in English
| IMSEAR
| ID: sea-49961
ABSTRACT
PURPOSE:
To assess the efficacy and safety of high dose thalidomide therapy for longer duration of time in relapsed or refractory Multiple Myeloma (MM) patients. MATERIALS ANDMETHODS:
Twelve relapsed/refractory MM patients (7 Males, 5 Females), who received thalidomide for more than 2 years were selected from the Out Patient Department of Institute Rotary Cancer Hospital (IRCH), AIIMS, India. Patients received thalidomide beginning at a dose of 200 mg/day with fortnightly increment to a maximum dose of 800 mg/day. Patients were assessed for response on the basis of M proteins (MP), bone marrow biopsy with touch preparation and skeletal X-rays.RESULTS:
Nine patients tolerated a maximum dose of 800 mg/day whereas three patients were given 600 mg/day. All patients showed > or = 25-50% decline in serum /urine M proteins. Complete response/ near complete response was seen in 50%, partial response in 17% and minimal response (SD) in 34% patients. Median duration of thalidomide therapy was 47 months (range 29-60 months). Currently 11 patients are alive. TOXICITY Varying degree of constipation and sedation were seen universally. One patient had DVT, which responded to anti-coagulant therapy. Other toxic effects included infections, skin reactions. There was no toxic death.CONCLUSION:
Long-term use of thalidomide is safe, effective and feasible. We feel that this is one of few reports describing safety and efficacy of long-term thalidomide in relapsed and refractory MM.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thalidomide
/
Time Factors
/
Aged
/
Female
/
Humans
/
Male
/
Prospective Studies
/
Constipation
/
Adult
/
Angiogenesis Inhibitors
Type of study:
Observational study
Language:
English
Journal:
Indian J Cancer
Year:
2007
Type:
Article
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