Secondary ANLL with t(11;19)(q23;p13) following etoposide and cisplatin for ovarian germ cell tumor.

Kapoor, G; Kadam, P R; Chougule, A; Gladstone, B; Advani, S H

Kapoor, G; Kadam, P R; Chougule, A; Gladstone, B; Advani, S H.

Indian J Cancer ; 1997 Jun; 34(2): 84-7

Article in English | IMSEAR | ID: sea-49982

ABSTRACT

ABSTRACT

This is a case report of a ten year old girl with ovarian germ cell tumor who was successfully treated with BEP chemotherapy. She developed acute myloid leukemia, AML-M5 with t(11;19)(q23;p13), 29 months after being off therapy. She received a cumulative dose of 2000 mg/m2 of etoposide and 400 mg/m2 of cisplatin. The association of etoposide and therapy related leukemia is reviewed.

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/adverse effects; Child; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 19; Cisplatin/administration & dosage; Etoposide/administration & dosage; Female; Germinoma/complications; Humans; Leukemia, Myeloid, Acute/chemically induced; Ovarian Neoplasms/complications; Translocation, Genetic

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Ovarian Neoplasms / Translocation, Genetic / Chromosomes, Human, Pair 11 / Chromosomes, Human, Pair 19 / Female / Humans / Leukemia, Myeloid, Acute / Antineoplastic Combined Chemotherapy Protocols / Child / Cisplatin Language: English Journal: Indian J Cancer Year: 1997 Type: Article

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