Safety and efficacy of cetuximab-chemotherapy combination in Saudi patients with metastatic colorectal cancer.
Indian J Cancer
;
2007 Apr-Jun; 44(2): 56-61
Article
in English
| IMSEAR
| ID: sea-50168
ABSTRACT
BACKGROUND:
Cetuximab-based combination chemotherapy (CBCC) proved safe and effective as second-line strategy for metastatic colorectal cancer (mCRC). This prospective phase-II study was designed to assess the efficacy and safety of CBCC as first-, second- or third-line among Saudi patients with mCRC. MATERIALS ANDMETHODS:
Patients with mCRC were offered CBCC to assess time-to-disease progression (TTP), response rate and duration, overall survival (OS) and safety.RESULTS:
Nineteen patients were eligible and their median age was 51 years. Seven patients received CBCC as first-line and 12 as second- or third-line. Responses 11 (58%) partial responses, 5 (26%) stable disease and 3 (16%) disease progressions. The median response duration was 4.3 months [95% confidence interval (CI) 3.4-5.2 months]. The median TTP was 6.8 months (95% CI 2-13.9 months) for all 19 patients compared to 9.3 months (95% CI 3.9-14.6 months) for the seven patients who received CBCC as first-line. The median OS for the entire population was 12.3 months (95% CI could not be determined). On the other hand, while the median OS for those who received CBCC as first-line have not been reached, the median OS for those who received CBCC after failure of other salvage therapies was 12.3 months (95% CI 3.2-21.4 months). CBCC was generally tolerable. One patient had a severe hypersensitivity reaction and another fatal cardiac arrest.CONCLUSION:
CBCC is active with an acceptable safety profile. Until results from phase-III clinical trials are available, using CBCC as first-line is probably justified.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organoplatinum Compounds
/
Saudi Arabia
/
Infusions, Intravenous
/
Aged
/
Female
/
Humans
/
Male
/
Camptothecin
/
Colorectal Neoplasms
/
Adenocarcinoma
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Cancer
Year:
2007
Type:
Article
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