Clinical utility of ketoconazole in cases of adrenocortical carcinoma.
Indian J Cancer
;
1991 Dec; 28(4): 196-201
Article
in English
| IMSEAR
| ID: sea-50258
ABSTRACT
Ketoconazole, an imidazole derivative is known to decrease adrenal steroid biosynthesis by inhibiting cytochrome P450 dependent adrenal enzymes. Three patients of adrenal carcinoma treated with ketoconazole, 600-1200 mg daily showed significant fall in plasma and urinary cortisol levels, but no reduction in tumor size, one patient developed liver dysfunction which reverted back to normal on discontinuing the drug.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Child
/
Adolescent
/
Adrenal Cortex Neoplasms
/
Adult
/
Ketoconazole
Language:
English
Journal:
Indian J Cancer
Year:
1991
Type:
Article
Similar
MEDLINE
...
LILACS
LIS