In vitro chemosensitivity profile of oral squamous cell cancer and its correlation with clinical response to chemotherapy.
Indian J Cancer
;
2007 Oct-Dec; 44(4): 142-6
Article
in English
| IMSEAR
| ID: sea-50825
ABSTRACT
CONTEXT Oral cancers represent a disparate group of tumors with diverse clinical behavior and chemosensitivity profile. Currently, it is difficult to predict whether a tumor will respond to chemotherapy and which drug(s) will achieve the maximum clinical response. AIMS:
To study in vitro chemosensitivity profile of oral cancers and to correlate the in vitro chemosensitivity of oral cancer to clinical response to chemotherapy. SETTINGS ANDDESIGN:
Prospective study in a tertiary cancer care center. METHODS ANDMATERIAL:
We prospectively studied the chemosensitivity profile of 57 untreated, advanced, unresectable oral cancers to cisplatin, methotrexate, 5-fluorouracil and their combinations by using histoculture drug response assay (HDRA) and correlated them to the clinical response to chemotherapy. STATISTICAL ANALYSIS USED Chi Square test.RESULTS:
Biopsy samples were successfully histocultured in 52/57 (91%) cases. Of these 52 evaluable patients, 47 had primary gingivo-buccal cancers and five had tongue / floor of mouth cancers. Based on the assay, 27 (52%) tumors were sensitive to cisplatin, 27 (52%) to methotrexate, 24 (46%) to 5-fluorouracil, 38 (73%) to combination of cisplatin and methotrexate and 36 (69%) to combination of cisplatin and 5-fluorouracil. Of these, 31 patients with good performance status received two cycles of chemotherapy using one or more of these test drugs. There was a significant correlation (p=0.03) between the in vitro chemosensitivity and the clinical response. Negative predictive value of the test was 80%, positive predictive value-69%, sensitivity-79% and specificity -71%. The overall accuracy of the assay was 74%.CONCLUSIONS:
We found HDRA to be a fairly good predictor of chemo-response of oral cancer.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Biological Assay
/
Female
/
Humans
/
Male
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Methotrexate
/
Prospective Studies
/
Cisplatin
/
Treatment Outcome
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Indian J Cancer
Year:
2007
Type:
Article
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