Three cases of extrapulmonary small cell carcinoma occurring in the prostate, stomach, and pancreas.
Indian J Cancer
;
1994 Dec; 31(4): 268-73
Article
in English
| IMSEAR
| ID: sea-51254
ABSTRACT
Small cell carcinomas are fairly common neoplasms in the lung, but tumors featuring similar histological profiles may occur in extrapulmonary organs. Three cases of small cell carcinomas occurring in the prostate (case 1), stomach (case 2), and pancreas (case 3) are presented. Production of hormones was demonstrated immunohistochemically in all cases. In case 2 alpha-fetoprotein (AFP) was elevated in the serum and observed immunohistochemically in tumor cells. Production of AFP is a distinctive feature, which has not been reported in the pulmonary and extrapulmonary cases of small cell carcinoma. Amplification and/or expression of myc gene family have been suggested to be related to the prognosis of pulmonary small cell carcinoma. Amplification of myc genes was not detected in any of our cases, but c-myc protein was demonstrated immunohistochemically in tumor cells of case 1.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pancreas
/
Pancreatic Neoplasms
/
Prostate
/
Prostatic Neoplasms
/
Stomach
/
Stomach Neoplasms
/
Aged
/
Female
/
Humans
/
Male
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Cancer
Year:
1994
Type:
Article
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