Expression of E-cadherin in primary oral squamous cell carcinoma and metastatic lymph nodes: an immunohistochemical study.
Article
in English
| IMSEAR
| ID: sea-51592
ABSTRACT
BACKGROUND:
E-cadherin plays an important role in cell-to-cell adhesion and cell motility and its loss is associated with oral squamous cell carcinoma (OSCC) progression. The aim of this study was to determine the expression of E-cadherin in various grades of OSCC and to correlate changes in the expression between these various grades and metastatic lymph nodes. MATERIALS ANDMETHODS:
Immunohistochemistry (IHC) was used to detect E-cadherin expression in normal oral mucosa, primary OSCC (n = 37), and metastatic lymph nodes (n = 10). E-cadherin immunoreactivity was correlated with grades of differentiation and with clinicopathological features.RESULTS:
E-cadherin immunoreactivity was found to inversely correlate with the loss of cell differentiation. The expression of E-cadherin decreased significantly in advanced cases of OSCC. However, increase in E-cadherin immunoreactivity was seen in early lesions, that is, in well differentiated (n = 9) and moderately differentiated OSCC (n = 13). Furthermore, E-cadherin was negative in majority of metastatic lymph nodes (7/10).CONCLUSIONS:
Loss of the cell adhesion and E-cadherin plays an important role in progression of OSCC, that is, down regulation of its expression is associated with de-differentiation and metastasis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Biomarkers, Tumor
/
Cadherins
/
Down-Regulation
/
Gene Expression Regulation, Neoplastic
/
Cell Adhesion
/
Cell Differentiation
/
Immunoenzyme Techniques
Language:
English
Year:
2009
Type:
Article
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