Antibacterial activity of ciprofloxacin-beta-cyclodextrin complex and its efficacy in dental implants.
Article
in English
| IMSEAR
| ID: sea-51736
ABSTRACT
Ciprofloxacin forms an inclusion complex with beta-cyclodextrin. The in vitro antibacterial activity of ciprofloxacin on E. coli and Staphylococcus aureus was found better on complexation. The complex was found very effective as a local antibacterial agent when used in dental implants. Significant reduction in the gingival index, probing pocket depth and microbial growth coupled with gain in attachment at the test site compared to control on the 14th day was observed when the implants containing 2.0 mg of the complex equivalent to 0.4 mg of ciprofloxacin was used in clinical trials.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Periodontal Pocket
/
Staphylococcus aureus
/
Humans
/
Ciprofloxacin
/
Microbial Sensitivity Tests
/
Periodontal Index
/
Adult
/
Cyclodextrins
/
Beta-Cyclodextrins
/
Dose-Response Relationship, Drug
Language:
English
Year:
1995
Type:
Article
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