Study of desmoglein 1 and 3 antibody levels in relation to disease severity in Indian patients with pemphigus.
Indian J Dermatol Venereol Leprol
;
2006 May-Jun; 72(3): 203-6
Article
in English
| IMSEAR
| ID: sea-52033
ABSTRACT
OBJECTIVES:
To conduct a cross-sectional study to compare Dsg1 and Dsg3 antibody levels independently with severity of disease activity in pemphigus vulgaris (PV) and pemphigus foliaceus (PF).METHODS:
Blood samples from 44 patients with pemphigus (PV-38, PF-6) were analyzed using ELISA. The severity of skin and mucosal disease was graded using a score from 0 to 3.RESULTS:
A statistically significant correlation between increase in Dsg 3 antibody titres with severity of oral involvement and Dsg 1 titres with severity of skin involvement was found in both PV and PF patients (p < 0.01). However, we were unable to demonstrate a relationship between increased titres of Dsg1 and Dsg 3 antibodies with oral and skin involvement respectively.CONCLUSION:
This study suggests that the severity of skin and oral disease in pemphigus is determined by the quantities of Dsg1 and Dsg3 antibodies respectively.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Enzyme-Linked Immunosorbent Assay
/
Case-Control Studies
/
Child
/
Cross-Sectional Studies
/
Adolescent
/
Pemphigus
/
Adult
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2006
Type:
Article
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