Immune reconstitution inflammatory syndrome.
Indian J Dermatol Venereol Leprol
;
2008 Nov-Dec; 74(6): 619-21
Article
in English
| IMSEAR
| ID: sea-52227
ABSTRACT
BACKGROUND:
Immune reconstitution inflammatory syndrome (IRIS) is a paradoxical deterioration in clinical status in a patient on antiretroviral treatment (ART) despite satisfactory control of viral replication and improvement of CD4 count.AIM:
To study development of IRIS as a part of ART.METHODS:
Hundred patients on antiretroviral treatment were studied prospectively in the Department of Skin and VD over a period of 2 years. Patients were asked to come if they developed any symptoms or on a monthly basis. They were screened clinically and investigated suitably for evidence of opportunistic infections.RESULTS:
Out of 100 patients, 10 patients did not come for follow-up. Twenty (22.2%) out of the 90 patients developed IRIS. Herpes zoster (HZ), herpes simplex virus (HSV), and tuberculosis (TB) were the cases of IRIS seen in the present study.CONCLUSIONS:
IRIS in terms of HSV/TB is known to accelerate HIV disease progression. Hence early detection and prompt treatment, along with continuation of highly active ART, are of utmost importance.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Screening study
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2008
Type:
Article
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