Stevens Johnson syndrome, toxic epidermal necrolysis and SJS-TEN overlap: a retrospective study of causative drugs and clinical outcome.
Indian J Dermatol Venereol Leprol
;
2008 May-Jun; 74(3): 238-40
Article
in English
| IMSEAR
| ID: sea-52258
ABSTRACT
BACKGROUND AND AIMS:
Stevens Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and SJS-TEN overlap are serious adverse cutaneous drug reactions. Drugs are often implicated in these reactions.METHODS:
A retrospective analysis of inpatients' data with these dermatological diagnoses were carried out for three years, to study the causative drugs, clinical outcome, and mortality in these conditions.RESULTS:
Thirty patients (15 TEN, nine SJS-TEN overlap, and six SJS) were admitted. In 21 cases, multiple drugs were implicated whereas single drugs were responsible in nine. Anticonvulsants (35.08%) were the most commonly implicated drugs followed by antibiotics (33.33%) and NSAIDS (24.56%). Twenty-five patients recovered whereas five died (four TEN, one SJS-TEN overlap).CONCLUSION:
Anticonvulsants, antibiotics and NSAIDs were the most frequently implicated drugs. TEN causes higher mortality than both SJS and SJS-TEN overlap.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aged
/
Female
/
Humans
/
Male
/
Child
/
Child, Preschool
/
Anti-Inflammatory Agents, Non-Steroidal
/
Retrospective Studies
/
Adolescent
/
Stevens-Johnson Syndrome
Type of study:
Observational study
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2008
Type:
Article
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