Darier's disease following radiotherapy for carcinoma of cervix.
Indian J Dermatol Venereol Leprol
;
2004 Sep-Oct; 70(5): 300-3
Article
in English
| IMSEAR
| ID: sea-52438
ABSTRACT
Darier-White disease is due to a defect in the ATP2A2 gene encoding the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA2b). We report a case of carcinoma cervix in whom Darier's disease manifested after the initiation of radiation therapy. Conventional cytogenetics on peripheral blood revealed non-clonal constitutional autosomal and X chromosome abnormalities suggesting radiation induced gene toxicity. Occurrence of Darier's disease in our case could be due to treatment induced sustained differentiation in the Darier's affected skin by an unknown mechanism. Late onset or sporadic Darier's disease is the other possibility.
Full text:
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Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2004
Type:
Article
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