Efficacy of low dose intravenous immunoglobulins in children with toxic epidermal necrolysis: an open uncontrolled study.
Indian J Dermatol Venereol Leprol
;
2005 Nov-Dec; 71(6): 398-400
Article
in English
| IMSEAR
| ID: sea-52746
ABSTRACT
BACKGROUND:
High dose intravenous immunoglobulins (IVIG) have emerged as a promising new therapy for treating the rare but potentially fatal drug reaction toxic epidermal necrolysis (TEN). Experimental in vitro studies support the view that IVIG can block the fas-fas ligand mediated apoptosis in TEN.METHODS:
Ten pediatric patients of TEN were treated with IVIG (0.05 - 0.1 gm/kg/day) along with antibiotics and supportive care.RESULTS:
Patients with 67% of mean body surface area of involvement showed an average of 2.1 days for arrest of progression of lesions and 8.1 days for complete reepithelization. There was no mortality.CONCLUSIONS:
Low dose IVIG appears to be a safe and effective treatment for TEN in children. Randomized trials are needed to further evaluate the efficacy of IVIG and compare it with other therapeutic modalities.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Child, Preschool
/
Stevens-Johnson Syndrome
/
Immunoglobulins, Intravenous
/
Immunologic Factors
/
Infant
Type of study:
Controlled clinical trial
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2005
Type:
Article
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