A study of oxidative stress in paucibacillary and multibacillary leprosy.
Indian J Dermatol Venereol Leprol
;
2008 Jan-Feb; 74(1): 80
Article
in English
| IMSEAR
| ID: sea-52860
ABSTRACT
BACKGROUND:
The study and assessment of oxidative stress plays a significant role in the arena of leprosy treatment.Once the presence of oxidative stress is proved, antioxidant supplements can be provided to reduce tissue injury and deformity.AIM:
To study oxidative stress in paucibacillary (PB) and multibacillary (MB) leprosy and to compare it with that in a control group.METHODS:
Fifty-eight untreated leprosy patients (23 PB and 35 MB cases) were studied and compared with 58 healthy controls. Superoxide dismutase (SOD) level as a measure of antioxidant status; malondialdehyde (MDA)level, an indicator of lipid peroxidation; and MDA/SOD ratio, an index of oxidative stress were estimated in the serum.RESULTS:
The SOD level was decreased in leprosy patients, especially in MB leprosy. The MDA level was increased in PB and MB leprosy. The MDA/SOD ratio was significantly elevated in MB patients. There was a steady increase in this ratio along the spectrum from tuberculoid to lepromatous leprosy (LL).CONCLUSION:
There is increased oxidative stress in MB leprosy, especially in LL. This warrants antioxidant supplements to prevent tissue injury.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Skin
/
Superoxide Dismutase
/
Humans
/
Lipid Peroxidation
/
Child
/
Child, Preschool
/
Adolescent
/
Oxidative Stress
/
Adult
/
Leprosy
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2008
Type:
Article
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