Management of premenstrual acne with Cox-2 inhibitors: a placebo controlled study.
Indian J Dermatol Venereol Leprol
;
2004 Nov-Dec; 70(6): 345-8
Article
in English
| IMSEAR
| ID: sea-52955
ABSTRACT
BACKGROUND:
Premenstrual acne is poorly understood, the accepted hypothesis is 30 years old.AIMS:
Here we test the hypothesis that premenstrual acne can be suppressed using Cox-2 inhibitors.METHODS:
Eighty women with premenstrual acne were enrolled in a trial where they were given rofecoxib, a Cox-2 inhibitor or placebo for 10 days for two cycles and were evaluated using acne severity index and inflammatory acne counts.RESULTS:
Rofecoxib was more effective than the placebo.CONCLUSIONS:
Although the number studied is small, the results suggest that rofecoxib is effective in the management of premenstrual acne and that prostaglandin PGE2 may be involved in its pathogenesis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Controlled clinical trial
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2004
Type:
Article
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