Ligand-binding prediction for ErbB2, a key molecule in the pathogenesis of leprosy.
Indian J Dermatol Venereol Leprol
;
2008 Jan-Feb; 74(1): 32-4
Article
in English
| IMSEAR
| ID: sea-52980
ABSTRACT
BACKGROUND AND AIMS:
Mycobacterium leprae is an obligate intracellular pathogen. Ligand-binding is an important factor in the success of chemoprevention and chemotherapy. A new drug that can inhibit M. leprae binding to and activation of, ErbB2 and Erk1/2 in primary Schwann cells is the new therapeutic option. However, the ligand-binding pattern of ErbB2 has never been clarified.METHODS:
In this work, the author performed a ligand-binding prediction for ErbB2 using a new bioinformatics tool.RESULTS:
According to this study, nine strong possible ligands can be identified.CONCLUSION:
These sites can be useful for further drug-development studies.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Protein Binding
/
Virulence
/
Binding Sites
/
Humans
/
Drug Design
/
Predictive Value of Tests
/
Receptor, ErbB-2
/
Computational Biology
/
Leprosy
/
Ligands
Type of study:
Etiology study
/
Prognostic study
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2008
Type:
Article
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