Langerhans cell histiocytosis of skin: a clinicopathologic analysis of five cases.
Indian J Dermatol Venereol Leprol
;
2006 May-Jun; 72(3): 211-4
Article
in English
| IMSEAR
| ID: sea-53042
ABSTRACT
BACKGROUND AND AIMS:
Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of histiocytes characterized by a proliferation of abnormal and clonal Langerhans cells. We retrospectively studied clinicopathologic features of this disorder in five cases.METHODS:
Clinical and histopathological findings of five cases of cutaneous LCH were reviewed based on the hospital records.RESULTS:
The age of patients ranged from 28 days to 5 years and M F ratio was 11.5. Clinically, the diagnoses suggested were histiocytosis, varicella, transient neonatal pustular melanosis, keloid, sarcoidosis, seborrheic keratosis and LCH. The most common type of skin lesion was a generalized papular lesion. Histologically, all cases showed aggregates of large mononuclear histiocytes (Langerhans cells) with reniform, irregular, cleaved nuclei and abundant eosinophilic cytoplasm. There was multi-systemic involvement in two patients and single-system involvement in three patients.CONCLUSION:
Cutaneous lesions may be the sole presenting feature of LCH. Diagnosis is based on demonstration of S-100 positive histiocytes.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Skin
/
Female
/
Humans
/
Male
/
Infant, Newborn
/
Child, Preschool
/
Langerhans Cells
/
Histiocytosis, Langerhans-Cell
/
Retrospective Studies
/
Adult
Type of study:
Observational study
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2006
Type:
Article
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