Plasma endothelin-1, homocysteine and serum nitric oxide values in patients with left-to-right shunt.
Indian Heart J
;
2004 Nov-Dec; 56(6): 653-7
Article
in English
| IMSEAR
| ID: sea-5334
ABSTRACT
BACKGROUND:
This study aimed to evaluate the effect of pulmonary blood flow and pulmonary hypertension on plasma endothelin-1, homocysteine and serum nitric oxide levels in patients with left-to-right shunt lesions with pulmonary hypertension and also with normal pulmonary arterial pressure. METHODS ANDRESULTS:
Plasma endothelin-1, homocysteine and nitric oxide levels were measured in 44 patients (Group 1) with left-to-right shunt and normal pulmonary arterial pressure (Qp/Qs 2.1), 65 patients (Group 2) with left-to-right shunt and pulmonary hypertension (Qp/Qs 2.4), 20 healthy control subjects (Group 3), and 17 post-operative patients (Group 4). Plasma endothelin-1 and serum nitric oxide levels were significantly higher in Group 2 than in groups 1, 3, and 4 (p<0.001). Plasma homocysteine levels were significantly higher in Group 2 than in Groups 1 and 4 (p<0.001 and p<0.01, respectively).CONCLUSIONS:
The increase in serum nitric oxide levels in patients with left-to-right shunt and pulmonary hypertension may be attributed to the compensatory mechanism. However, this increase does not improve pulmonary hypertension because of increased endothelin-1 and homocysteine levels. In the light of present study, we conclude that vascular changes caused by increased homocysteine and endothelin-1 may provoke pulmonary hypertension in patients with left-to-right shunt.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Biomarkers
/
Case-Control Studies
/
Child, Preschool
/
Endothelin-1
/
Heart Defects, Congenital
/
Homocysteine
/
Hypertension, Pulmonary
Type of study:
Observational study
Language:
English
Journal:
Indian heart j
Year:
2004
Type:
Article
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