Aciclovir resistance among Indian strains of Herpes simplex virus as determined using a dye uptake assay.
Indian J Med Microbiol
;
2007 Jul; 25(3): 260-2
Article
in English
| IMSEAR
| ID: sea-53477
ABSTRACT
Resistance to aciclovir (ACV) among Herpes simplex virus (HSV) isolates is increasingly being reported in the literature particularly in immunocompromised patients. However, there is only limited data available from India despite widespread use of ACV in our hospital. A cross-sectional study was hence conducted to determine the aciclovir (ACV) susceptibility of HSV 1 and 2 isolates using a dye uptake (DU) assay. This study showed a 3.0% prevalence of ACV resistance among HSV-1 strains (2/66, median IC 50 0.098 microg/mL) while in HSV-2 strains, it was 7.8% (5/64, median IC 50 0.195 microg/mL). The IC 50 for the HSV-1 and HSV-2 strains resistant to ACV was greater than or equal to 6.25 microg/mL.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Antiviral Agents
/
Virology
/
Humans
/
Acyclovir
/
Microbial Sensitivity Tests
/
Cross-Sectional Studies
/
Simplexvirus
/
Drug Resistance, Viral
/
India
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Med Microbiol
Journal subject:
Microbiology
Year:
2007
Type:
Article
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