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Gastrointestinal histoplasmosis presenting as colonic pseudotumour.
Indian J Med Microbiol ; 2008 Apr-Jun; 26(2): 187-9
Article in English | IMSEAR | ID: sea-53498
ABSTRACT
We report a case of gastrointestinal histoplasmosis in a 45-year-old HIV positive man who was misdiagnosed as a case of colonic cancer. The patient presented with low-grade fever, pain in lower abdomen, anorexia and weight loss of six months duration. On examination a lump in the left iliac fossa was detected. Colonoscopy revealed stricture and ulcerated growth in the sigmoid colon. Radiological investigations suggested malignant/inflammatory mass in the sigmoid colon with luminal compromise. Patient was operated and ulcerated tissue was sent for histopathological examination, which revealed numerous intracellular, 2-4 microm, oval, narrow-based budding yeast cells suggestive of Histoplasma capsulatum. Subsequently, the patient developed fluffy opacities on X-ray chest. Examination of sputum revealed presence of acid-fast bacilli and yeast forms of H. capsulatum. Patient was started on amphotericin B but died on the seventeenth postoperative day. The diagnosis of histoplasmosis was made retrospectively. Atypical presentation and rarity of the disease led to this diagnostic pitfall. To the best of our knowledge this is the first report of gastrointestinal histoplasmosis presenting as colonic pseudotumour from India.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Colon, Sigmoid / Sputum / Humans / Male / HIV Infections / Amphotericin B / Colonoscopy / Colonic Diseases / Fatal Outcome / Granuloma, Plasma Cell Country/Region as subject: Asia Language: English Journal: Indian J Med Microbiol Journal subject: Microbiology Year: 2008 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Colon, Sigmoid / Sputum / Humans / Male / HIV Infections / Amphotericin B / Colonoscopy / Colonic Diseases / Fatal Outcome / Granuloma, Plasma Cell Country/Region as subject: Asia Language: English Journal: Indian J Med Microbiol Journal subject: Microbiology Year: 2008 Type: Article