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High level ciprofloxacin resistance in Salmonella enterica isolated from blood.
Indian J Med Microbiol ; 2008 Jan-Mar; 26(1): 50-3
Article in English | IMSEAR | ID: sea-53507
ABSTRACT

PURPOSE:

Over the last few years, resistance to ciprofloxacin in Salmonella enterica has become a global concern. The present study was undertaken to find out the susceptibility pattern of Salmonella enterica isolates in our hospital.

METHODS:

Blood cultures were done using BacT/ALERT 3D system. The antimicrobial susceptibility testing was carried out by the Kirby-Bauer disc diffusion method using CLSI breakpoints. Minimum inhibitory concentration was determined for ciprofloxacin-resistant strains using E-test and Vitek-1 automated system.

RESULTS:

A total of 25,953 samples of blood culture yielded 431 Salmonella enterica serotype Typhi and 198 serotype Paratyphi A isolates. Twenty-two isolates of serotype Typhi were resistant to ciprofloxacin, while two isolates of Typhi and two Paratyphi A were intermediately susceptible to ciprofloxacin. Ciprofloxacin resistance is 5.6% (24 isolates) among Salmonella enterica serotype Typhi. Ampicillin, chloramphenicol and co-trimoxazole resistance in Salmonella enterica serotype Typhi appears to have decreased to 14.9% (64/431) in comparison to the 27% (55/205) during 2003. All isolates were sensitive to ceftriaxone.

CONCLUSIONS:

Ciprofloxacin can no longer be considered as the drug of choice in treating Salmonella infections. While first-line antimicrobials may still have a role to play in the treatment of enteric fever, ceftriaxone remains the sole defence against ciprofloxacin-resistant Salmonella infections.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Salmonella paratyphi A / Salmonella typhi / Typhoid Fever / Blood / Humans / Ciprofloxacin / Microbial Sensitivity Tests / Bacteremia / Paratyphoid Fever / Drug Resistance, Bacterial Language: English Journal: Indian J Med Microbiol Journal subject: Microbiology Year: 2008 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Salmonella paratyphi A / Salmonella typhi / Typhoid Fever / Blood / Humans / Ciprofloxacin / Microbial Sensitivity Tests / Bacteremia / Paratyphoid Fever / Drug Resistance, Bacterial Language: English Journal: Indian J Med Microbiol Journal subject: Microbiology Year: 2008 Type: Article